Why Choose
Hixia?
Expertise in a broad range of heterocyclic systems including:
Indoles [2,3,5 and 8 substituted]
Quinolines
Fused and unfused tetrazoles and triazoles
Quinazolines
Pyrimidines
Pyridines
Methylene dioxybenzene derivatives
Furan chemistry
Expertise in the following areas of chemistry and functional group creation / manipulation:
Nitration
Halogenation,
Azide and aza Wittig chemistry
Boronic acids
High pressure phosphorus oxychloride chemistry
Reduction including Pt, Pd
Hydrogenation including use of chiral ligands
Grignard and Lithium chemistry
Phosgenation
Asymmetric synthesis
Dipolar cycloaddition chemistry
Enzymatic chiral resolution including hydrolase, esterase, dehalogenase
Equipment Available:
Manufacturing equipment:
Glass and stainless steel to 50L
Operating temperatures –80 to 300oC
Specialist manufacturing equipment:
High pressure Hastalloy reactors 1-4L max operating pressure 275 barg and –80oC to 300oC
High pressure Stainless steel reactors 1-25L max operating pressure 250 barg and –80oC to 300oC
High pressure Glass reactors 1-3L max operating pressure 5 barg and –80oC to 300oC
High Vacuum distillation equipment 0.01mmHg 50 theoretical plates
Analytical Facilities Available:
Nuclear Magnetic Spectroscopy:
400MHz FT NMR
500 & 600MHz available upon request
Multinuclear Spectroscopy
NOE, cosey
High Pressure Liquid Chromatography:
Mono and binary systems available
HPLC-MS available upon request
Mass Spectroscopy:
C.I. / E.I. / FAB
MALDI-TOF
The following techniques are also available:
FT-IR
UV-Vis
Karl-Fisher
Polarimeter
Elemental Analysis
Sulphated Ash
GC (including residual solvents)
Atomic absorption
X-Ray crystallography
DNA microarray (chip) Technology:
Including manufacture of Photo-labile blocking groups
e.g. MeNPOC or [R,S]-1-[3,4-[methylene-dioxy]-6-nitrophenyl] ethyl chloroformate)
Fluorescence Labelling Technology:
Including sialic acid derivatisating agents
e.g. DMB 1,2-Diamino-4,5-methylenedioxybenzene CAS 818-15-5