Why Choose

Hixia?

Expertise in a broad range of heterocyclic systems including: 

Indoles [2,3,5 and 8 substituted]

Quinolines

Fused and unfused tetrazoles and triazoles

Quinazolines

Pyrimidines

Pyridines

Methylene dioxybenzene derivatives

Furan chemistry

 

Expertise in the following areas of chemistry and functional group creation / manipulation: 

Nitration 

Halogenation, 

Azide and aza Wittig chemistry 

Boronic acids 

High pressure phosphorus oxychloride chemistry 

Reduction including Pt, Pd 

Hydrogenation including use of chiral ligands 

Grignard and Lithium chemistry 

Phosgenation 

Asymmetric synthesis 

Dipolar cycloaddition chemistry 

Enzymatic chiral resolution including hydrolase, esterase, dehalogenase 

 

Equipment Available:

Manufacturing equipment:

Glass and stainless steel to 50L

Operating temperatures –80 to 300oC 

Specialist manufacturing equipment:

High pressure Hastalloy reactors 1-4L max operating pressure 275 barg and –80oC to 300oC

High pressure Stainless steel reactors 1-25L max operating pressure 250 barg and –80oC to 300oC 

High pressure Glass reactors 1-3L max operating pressure 5 barg and –80oC to 300oC 

High Vacuum distillation equipment 0.01mmHg 50 theoretical plates 

 

Analytical Facilities Available:

Nuclear Magnetic Spectroscopy:

 

400MHz FT NMR 

500 & 600MHz available upon request 

Multinuclear Spectroscopy 

NOE, cosey 

 

High Pressure Liquid Chromatography: 

Mono and binary systems available 

HPLC-MS available upon request 

 

Mass Spectroscopy:

C.I. / E.I. /  FAB 

MALDI-TOF

 

The following techniques are also available:

FT-IR

UV-Vis

Karl-Fisher

Polarimeter

Elemental Analysis

Sulphated Ash

GC (including residual solvents)

Atomic absorption

X-Ray crystallography 

 

DNA microarray (chip) Technology:

Including manufacture of Photo-labile blocking groups 

e.g. MeNPOC or [R,S]-1-[3,4-[methylene-dioxy]-6-nitrophenyl] ethyl chloroformate)

Fluorescence Labelling Technology:

Including sialic acid derivatisating agents

e.g.  DMB 1,2-Diamino-4,5-methylenedioxybenzene CAS 818-15-5

Daresbury Innovation Centre 
International Science & Technical Park 
Daresbury Cheshire 
WA4 4FS

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